Background: Whole-genome sequencing projects are rapidly producing an enormous number of new sequences. Consequently almost every family of proteins now contains hundreds of membe...
Background: At intermediate stages of genome assembly projects, when a number of contigs have been generated and their validity needs to be verified, it is desirable to align thes...
Background: Molecular database search tools need statistical models to assess the significance for the resulting hits. In the classical approach one asks the question how probable...
Stefan Wolfsheimer, Inke Herms, Sven Rahmann, Alex...
Background: Comparing related structures and viewing the structures in the context of sequence alignments are important tasks in protein structure-function research. While many pr...
Elaine C. Meng, Eric F. Pettersen, Gregory S. Couc...
In recent years, homology-based and signal-based methods have been proposed for predicting the subcellular localization of proteins. While it has been known that homology-based me...