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BMCBI
2010
105views more  BMCBI 2010»
13 years 7 months ago
Comparison of PGH2 binding site in prostaglandin synthases
Background: Prostaglandin H2 (PGH2) is a common precursor for the synthesis of five different Prostanoids via specific Prostanoid Synthases. The binding of this substrate with the...
Padmapriya Paragi-Vedanthi, Mukesh Doble
BMCBI
2010
116views more  BMCBI 2010»
13 years 7 months ago
A hybrid approach to protein folding problem integrating constraint programming with local search
Background: The protein folding problem remains one of the most challenging open problems in computational biology. Simplified models in terms of lattice structure and energy func...
Abu Zafer M. Dayem Ullah, Kathleen Steinhöfel
BMCBI
2010
156views more  BMCBI 2010»
13 years 7 months ago
Estimating the individualized HIV-1 genetic barrier to resistance using a nelfinavir fitness landscape
Background: Failure on Highly Active Anti-Retroviral Treatment is often accompanied with development of antiviral resistance to one or more drugs included in the treatment. In gen...
Kristof Theys, Koen Deforche, Gertjan Beheydt, Yve...
BMCBI
2008
144views more  BMCBI 2008»
13 years 7 months ago
Local conservation scores without a priori assumptions on neutral substitution rates
Background: Comparative genomics aims to detect signals of evolutionary conservation as an indicator of functional constraint. Surprisingly, results of the ENCODE project revealed...
Janis Dingel, Pavol Hanus, Niccolò Leonardi...
BMCBI
2010
136views more  BMCBI 2010»
13 years 7 months ago
Protein structure analysis of mutations causing inheritable diseases. An e-Science approach with life scientist friendly interfa
Background: Many newly detected point mutations are located in protein-coding regions of the human genome. Knowledge of their effects on the protein's 3D structure provides i...
Hanka Venselaar, Tim A. H. te Beek, Remko K. P. Ku...