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BMCBI
2010
89views more  BMCBI 2010»
13 years 8 months ago
Spatial normalization improves the quality of genotype calling for Affymetrix SNP 6.0 arrays
Background: Microarray measurements are susceptible to a variety of experimental artifacts, some of which give rise to systematic biases that are spatially dependent in a unique w...
High-Seng Chai, Terry M. Therneau, Kent R. Bailey,...
BMCBI
2010
149views more  BMCBI 2010»
13 years 8 months ago
Identifying common prognostic factors in genomic cancer studies: A novel index for censored outcomes
Background: With the growing number of public repositories for high-throughput genomic data, it is of great interest to combine the results produced by independent research groups...
Sigrid Rouam, Thierry Moreau, Philippe Broët
BMCBI
2010
156views more  BMCBI 2010»
13 years 8 months ago
Adaptive coarse-grained Monte Carlo simulation of reaction and diffusion dynamics in heterogeneous plasma membranes
Background: An adaptive coarse-grained (kinetic) Monte Carlo (ACGMC) simulation framework is applied to reaction and diffusion dynamics in inhomogeneous domains. The presented mod...
Stuart Collins, Michail Stamatakis, Dionisios G. V...
BMCBI
2010
104views more  BMCBI 2010»
13 years 8 months ago
Bidirectional best hit r-window gene clusters
Background: Conserved gene clusters are groups of genes that are located close to one another in the genomes of several species. They tend to code for proteins that have a functio...
Melvin Zhang, Hon Wai Leong
BMCBI
2010
167views more  BMCBI 2010»
13 years 8 months ago
Bi-directional gene set enrichment and canonical correlation analysis identify key diet-sensitive pathways and biomarkers of met
Background: Currently, a number of bioinformatics methods are available to generate appropriate lists of genes from a microarray experiment. While these lists represent an accurat...
Melissa J. Morine, Jolene McMonagle, Sinead Toomey...