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BMCBI
2010
154views more  BMCBI 2010»
13 years 8 months ago
An algorithm for automated closure during assembly
Background: Finishing is the process of improving the quality and utility of draft genome sequences generated by shotgun sequencing and computational assembly. Finishing can invol...
Sergey Koren, Jason R. Miller, Brian Walenz, Grang...
BMCBI
2008
193views more  BMCBI 2008»
13 years 8 months ago
Missing value imputation for microarray gene expression data using histone acetylation information
Background: It is an important pre-processing step to accurately estimate missing values in microarray data, because complete datasets are required in numerous expression profile ...
Qian Xiang, Xianhua Dai, Yangyang Deng, Caisheng H...
BMCBI
2010
105views more  BMCBI 2010»
13 years 8 months ago
Subdivision of the MDR superfamily of medium-chain dehydrogenases/reductases through iterative hidden Markov model refinement
Background: The Medium-chain Dehydrogenases/Reductases (MDR) form a protein superfamily whose size and complexity defeats traditional means of subclassification; it currently has ...
Joel Hedlund, Hans Jörnvall, Bengt Persson
BMCBI
2008
123views more  BMCBI 2008»
13 years 8 months ago
Shape based indexing for faster search of RNA family databases
Background: Most non-coding RNA families exert their function by means of a conserved, common secondary structure. The Rfam data base contains more than five hundred structurally ...
Stefan Janssen, Jens Reeder, Robert Giegerich
BMCBI
2008
154views more  BMCBI 2008»
13 years 8 months ago
GeNESiS: gene network evolution simulation software
Background: There has been a lot of interest in recent years focusing on the modeling and simulation of Gene Regulatory Networks (GRNs). However, the evolutionary mechanisms that ...
Anton Kratz, Masaru Tomita, Arun Krishnan