Background: Genome-wide association studies have been successful in finding common variants influencing common traits. However, these associations only account for a fraction of t...
Robert Lawrence, Aaron G. Day-Williams, Katherine ...
Background: Many newly detected point mutations are located in protein-coding regions of the human genome. Knowledge of their effects on the protein's 3D structure provides i...
Hanka Venselaar, Tim A. H. te Beek, Remko K. P. Ku...
Background: An important aspect of protein design is the ability to predict changes in protein thermostability arising from single- or multi-site mutations. Protein thermostabilit...
Background: Inferring gene regulatory networks from data requires the development of algorithms devoted to structure extraction. When only static data are available, gene interact...
Background: Many proposed statistical measures can efficiently compare protein sequence to further infer protein structure, function and evolutionary information. They share the s...