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BMCBI
2006
155views more  BMCBI 2006»
13 years 7 months ago
AffyMiner: mining differentially expressed genes and biological knowledge in GeneChip microarray data
Background: DNA microarrays are a powerful tool for monitoring the expression of tens of thousands of genes simultaneously. With the advance of microarray technology, the challeng...
Guoqing Lu, The V. Nguyen, Yuannan Xia, Michael Fr...
BMCBI
2006
130views more  BMCBI 2006»
13 years 7 months ago
MicroTar: predicting microRNA targets from RNA duplexes
Background: The accurate prediction of a comprehensive set of messenger RNAs (targets) regulated by animal microRNAs (miRNAs) remains an open problem. In particular, the predictio...
Rahul Thadani, Martti T. Tammi
BMCBI
2006
103views more  BMCBI 2006»
13 years 7 months ago
Cis-motifs upstream of the transcription and translation initiation sites are effectively revealed by their positional disequili
Background: The discovery of cis-regulatory motifs still remains a challenging task even though the number of sequenced genomes is constantly growing. Computational analyses using...
Kenneth W. Berendzen, Kurt Stüber, Klaus Hart...
BMCBI
2006
100views more  BMCBI 2006»
13 years 7 months ago
Using the nucleotide substitution rate matrix to detect horizontal gene transfer
Background: Horizontal gene transfer (HGT) has allowed bacteria to evolve many new capabilities. Because transferred genes perform many medically important functions, such as conf...
Micah Hamady, M. D. Betterton, Rob Knight
BMCBI
2006
130views more  BMCBI 2006»
13 years 7 months ago
4SALE - A tool for synchronous RNA sequence and secondary structure alignment and editing
Background: In sequence analysis the multiple alignment builds the fundament of all proceeding analyses. Errors in an alignment could strongly influence all succeeding analyses an...
Philipp N. Seibel, Tobias Müller, Thomas Dand...
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