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» Algorithms for Challenging Motif Problems
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EOR
2008
133views more  EOR 2008»
13 years 8 months ago
Investigating a hybrid simulated annealing and local search algorithm for constrained optimization
Constrained Optimization Problems (COP) often take place in many practical applications such as kinematics, chemical process optimization, power systems and so on. These problems ...
Chandra Sekhar Pedamallu, Linet Özdamar
BMCBI
2008
142views more  BMCBI 2008»
13 years 8 months ago
Microarray data mining: A novel optimization-based approach to uncover biologically coherent structures
Background: DNA microarray technology allows for the measurement of genome-wide expression patterns. Within the resultant mass of data lies the problem of analyzing and presenting...
Meng Piao Tan, Erin N. Smith, James R. Broach, Chr...
BMCBI
2006
137views more  BMCBI 2006»
13 years 8 months ago
A classification-based framework for predicting and analyzing gene regulatory response
Background: We have recently introduced a predictive framework for studying gene transcriptional regulation in simpler organisms using a novel supervised learning algorithm called...
Anshul Kundaje, Manuel Middendorf, Mihir Shah, Chr...
GECCO
2003
Springer
14 years 1 months ago
Hierarchical BOA Solves Ising Spin Glasses and MAXSAT
Abstract. Theoretical and empirical evidence exists that the hierarchical Bayesian optimization algorithm (hBOA) can solve challenging hierarchical problems and anything easier. Th...
Martin Pelikan, David E. Goldberg
BMCBI
2010
116views more  BMCBI 2010»
13 years 8 months ago
A hybrid approach to protein folding problem integrating constraint programming with local search
Background: The protein folding problem remains one of the most challenging open problems in computational biology. Simplified models in terms of lattice structure and energy func...
Abu Zafer M. Dayem Ullah, Kathleen Steinhöfel