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» Aligning Two Fragmented Sequences
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BMCBI
2004
141views more  BMCBI 2004»
13 years 9 months ago
Estimates of statistical significance for comparison of individual positions in multiple sequence alignments
Background: Profile-based analysis of multiple sequence alignments (MSA) allows for accurate comparison of protein families. Here, we address the problems of detecting statistical...
Ruslan Sadreyev, Nick V. Grishin
RECOMB
2003
Springer
14 years 10 months ago
Accurate detection of very sparse sequence motifs
Protein sequence alignments are more reliable the shorter the evolutionary distance. Here, we align distantly related proteins using many closely spaced intermediate sequences as ...
Andreas Heger, Michael Lappe, Liisa Holm
RECOMB
2002
Springer
14 years 10 months ago
Significance Of inter-species matches when evolutionary rate varies
We develop techniques to estimate the statistical significance of gap-free alignments between two genomic DNA sequences, using human-mouse alignments as an example. The sequences ...
Jia Li, Webb Miller
BIBE
2006
IEEE
132views Bioinformatics» more  BIBE 2006»
14 years 3 months ago
Simplicity in RNA Secondary Structure Alignment: Towards biologically plausible alignments
Ribonucleic acid (RNA) molecules contain the genetic information that regulates the functions of organisms. Given two different molecules, a preserved function corresponds to a pr...
Rimon Mikhaiel, Guohui Lin, Eleni Stroulia
MKM
2009
Springer
14 years 4 months ago
Unifying Math Ontologies: A Tale of Two Standards
Abstract. One of the fundamental and seemingly simple aims of mathematical knowledge management (MKM) is to develop and standardize formats that allow to “represent the meaning o...
James H. Davenport, Michael Kohlhase