Background: Two central problems in computational biology are the determination of the alignment and phylogeny of a set of biological sequences. The traditional approach to this p...
We describe a novel method for efficient reconstruction of phylogenetic trees, based on sequences of whole genomes or proteomes, whose lengths may greatly vary. The core of our me...
David Burstein, Igor Ulitsky, Tamir Tuller, Benny ...
Computing large multiple protein sequence alignments using progressive alignment tools such as ClustalW requires several hours on state-of-the-art workstations. ClustalW uses a th...
: Accurate reconstruction of phylogenetic trees very often involves solving hard optimization problems, particularly the maximum parsimony (MP) and maximum likelihood (ML) problems...
Cristian Coarfa, Yuri Dotsenko, John M. Mellor-Cru...
There are very few instances in which positive Darwinian selection has been convincingly demonstrated at the molecular level. In this study, we present a novel test for detecting p...
Tal Pupko, Roded Sharan, Masami Hasegawa, Ron Sham...