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» Alignments of RNA Structures
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BMCBI
2010
150views more  BMCBI 2010»
13 years 8 months ago
Evolutionary rates at codon sites may be used to align sequences and infer protein domain function
Background: Sequence alignments form part of many investigations in molecular biology, including the determination of phylogenetic relationships, the prediction of protein structu...
Pierre M. Durand, Scott Hazelhurst, Theresa L. Coe...
CSB
2005
IEEE
119views Bioinformatics» more  CSB 2005»
14 years 1 months ago
Temperature and Mutation Switches in the Secondary Structure of Small RNAs
Conformational switching in the secondary structure of RNAs has recently attracted considerable attention, fostered by the discovery of ‘riboswitches’ in living organisms. The...
Assaf Avihoo, Danny Barash
BIBE
2007
IEEE
128views Bioinformatics» more  BIBE 2007»
14 years 2 months ago
QOMA2: Optimizing the alignment of many sequences
Abstract—We consider the problem of aligning multiple protein sequences with the goal of maximizing the SP (Sum-of-Pairs) score, when the number of sequences is large. The QOMA (...
Xu Zhang, Tamer Kahveci
BMCBI
2005
123views more  BMCBI 2005»
13 years 8 months ago
PSI-BLAST-ISS: an intermediate sequence search tool for estimation of the position-specific alignment reliability
Background: Protein sequence alignments have become indispensable for virtually any evolutionary, structural or functional study involving proteins. Modern sequence search and com...
Mindaugas Margelevicius, Ceslovas Venclovas
BMCBI
2006
80views more  BMCBI 2006»
13 years 8 months ago
Quantification of the variation in percentage identity for protein sequence alignments
Background: Percentage Identity (PID) is frequently quoted in discussion of sequence alignments since it appears simple and easy to understand. However, although there are several...
G. P. S. Raghava, Geoffrey J. Barton