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» An Ant-Based Model for Multiple Sequence Alignment
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ISMB
1996
13 years 8 months ago
Parameterization Studies for the SAM and HMMER Methods of Hidden Markov Model Generation
Multiple sequence alignment of distantly related viral proteins remains a challenge to all currently available alignment methods. The hidden Markovmodel approach offers a new,flex...
Marcella A. McClure, Chris Smith, Pete Elton
NAR
1998
86views more  NAR 1998»
13 years 7 months ago
Pfam: multiple sequence alignments and HMM-profiles of protein domains
Pfam contains multiple alignments and hidden Markov model based profiles (HMM-profiles) of complete protein domains. The definition of domain boundaries, family members and alignm...
Erik L. L. Sonnhammer, Sean R. Eddy, Ewan Birney, ...
BMCBI
2005
122views more  BMCBI 2005»
13 years 7 months ago
Bayesian coestimation of phylogeny and sequence alignment
Background: Two central problems in computational biology are the determination of the alignment and phylogeny of a set of biological sequences. The traditional approach to this p...
Gerton Lunter, István Miklós, Alexei...
BIB
2006
141views more  BIB 2006»
13 years 7 months ago
Statistical significance in biological sequence analysis
One of the major goals of computational sequence analysis is to find sequence similarities, which could serve as evidence of structural and functional conservation, as well as of ...
Alexander Yu. Mitrophanov, Mark Borodovsky
ICASSP
2010
IEEE
13 years 6 months ago
Multiple sequence alignment based bootstrapping for improved incremental word learning
We investigate incremental word learning with few training examples in a Hidden Markov Model (HMM) framework suitable for an interactive learning scenario with little prior knowle...
Irene Ayllól Clemente, Martin Heckmann, Ger...