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BMCBI
2010
120views more  BMCBI 2010»
13 years 10 months ago
Modeling expression quantitative trait loci in data combining ethnic populations
Background: Combining data from different ethnic populations in a study can increase efficacy of methods designed to identify expression quantitative trait loci (eQTL) compared to...
Ching-Lin Hsiao, Ie-Bin Lian, Ai-Ru Hsieh, Cathy S...
BMCBI
2010
139views more  BMCBI 2010»
13 years 10 months ago
A highly efficient multi-core algorithm for clustering extremely large datasets
Background: In recent years, the demand for computational power in computational biology has increased due to rapidly growing data sets from microarray and other high-throughput t...
Johann M. Kraus, Hans A. Kestler
BMCBI
2010
208views more  BMCBI 2010»
13 years 10 months ago
Using machine learning to speed up manual image annotation: application to a 3D imaging protocol for measuring single cell gene
Background: Image analysis is an essential component in many biological experiments that study gene expression, cell cycle progression, and protein localization. A protocol for tr...
Zafer Aydin, John I. Murray, Robert H. Waterston, ...
BMCBI
2010
155views more  BMCBI 2010»
13 years 10 months ago
BISMA - Fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences
Background: Bisulfite sequencing is a popular method to analyze DNA methylation patterns at high resolution. A region of interest is targeted by PCR and about 20-50 subcloned DNA ...
Christian Rohde, Yingying Zhang, Richard Reinhardt...
BMCBI
2010
136views more  BMCBI 2010»
13 years 10 months ago
Bias correction and Bayesian analysis of aggregate counts in SAGE libraries
Background: Tag-based techniques, such as SAGE, are commonly used to sample the mRNA pool of an organism's transcriptome. Incomplete digestion during the tag formation proces...
Russell L. Zaretzki, Michael A. Gilchrist, William...
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