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CSB
2003
IEEE
14 years 20 days ago
An Exact Algorithm For Determining Protein Backbone Structure From NH Residual Dipolar Couplings
We have developed a novel algorithm for protein backbone structure determination using global orientational restraints on internuclear bond vectors derived from residual dipolar c...
Lincong Wang, Ramgopal R. Mettu, Ryan H. Lilien, B...
CSB
2003
IEEE
176views Bioinformatics» more  CSB 2003»
14 years 20 days ago
3D Structural Homology Detection via Unassigned Residual Dipolar Couplings
Recognition of a protein’s fold provides valuable information about its function. While many sequence-based homology prediction methods exist, an important challenge remains: tw...
Christopher James Langmead, Bruce Randall Donald
CSB
2005
IEEE
136views Bioinformatics» more  CSB 2005»
14 years 1 months ago
An Algebraic Geometry Approach to Protein Structure Determination from NMR Data
Our paper describes the first provably-efficient algorithm for determining protein structures de novo, solely from experimental data. We show how the global nature of a certain ...
Lincong Wang, Ramgopal R. Mettu, Bruce Randall Don...
CSB
2004
IEEE
177views Bioinformatics» more  CSB 2004»
13 years 11 months ago
High-Throughput 3D Structural Homology Detection via NMR Resonance Assignment
One goal of the structural genomics initiative is the identification of new protein folds. Sequence-based structural homology prediction methods are an important means for priorit...
Christopher James Langmead, Bruce Randall Donald