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» An Experimental Study of Data Migration Algorithms
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VLDB
1999
ACM
140views Database» more  VLDB 1999»
13 years 11 months ago
Combining Histograms and Parametric Curve Fitting for Feedback-Driven Query Result-size Estimation
This paper aims to improve the accuracy of query result-size estimations in query optimizers by leveraging the dynamic feedback obtained from observations on the executed query wo...
Arnd Christian König, Gerhard Weikum
KDD
2010
ACM
252views Data Mining» more  KDD 2010»
13 years 11 months ago
Fast query execution for retrieval models based on path-constrained random walks
Many recommendation and retrieval tasks can be represented as proximity queries on a labeled directed graph, with typed nodes representing documents, terms, and metadata, and labe...
Ni Lao, William W. Cohen
BMCBI
2010
105views more  BMCBI 2010»
13 years 7 months ago
A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
Tiejun Cheng, Zhihai Liu, Renxiao Wang
BMCBI
2010
121views more  BMCBI 2010»
13 years 7 months ago
Knowledge-based annotation of small molecule binding sites in proteins
Background: The study of protein-small molecule interactions is vital for understanding protein function and for practical applications in drug discovery. To benefit from the rapi...
Ratna R. Thangudu, Manoj Tyagi, Benjamin A. Shoema...
BMCBI
2006
153views more  BMCBI 2006»
13 years 7 months ago
Discovery of time-delayed gene regulatory networks based on temporal gene expression profiling
Background: It is one of the ultimate goals for modern biological research to fully elucidate the intricate interplays and the regulations of the molecular determinants that prope...
Xia Li, Shaoqi Rao, Wei Jiang, Chuanxing Li, Yun X...