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BMCBI
2010
116views more  BMCBI 2010»
13 years 8 months ago
Optimization algorithms for functional deimmunization of therapeutic proteins
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...
Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chr...
PPSC
1997
13 years 9 months ago
Case Studies in Protein Structure Prediction with Real-valued Genetic Algorithms
Accurate and reliable protein structure prediction (PSP) eludes researchers primarily becausethe searchfor theminimumenergyconformeris computationallyintractable. This research di...
Charles E. Kaiser, Laurence D. Merkle, Gary B. Lam...
BIBM
2008
IEEE
217views Bioinformatics» more  BIBM 2008»
14 years 2 months ago
Combining Hierarchical Inference in Ontologies with Heterogeneous Data Sources Improves Gene Function Prediction
The study of gene function is critical in various genomic and proteomic fields. Due to the availability of tremendous amounts of different types of protein data, integrating thes...
Xiaoyu Jiang, Naoki Nariai, Martin Steffen, Simon ...
ISMB
1994
13 years 9 months ago
Predicting Location and Structure Of beta-Sheet Regions Using Stochastic Tree Grammars
We describe and demonstrate the effectiveness of a method of predicting protein secondary structures, sheet regions in particular, using a class of stochastic tree grammars as rep...
Hiroshi Mamitsuka, Naoki Abe
BIBM
2010
IEEE
156views Bioinformatics» more  BIBM 2010»
13 years 6 months ago
Truncation of protein sequences for fast profile alignment with application to subcellular localization
We have recently found that the computation time of homology-based subcellular localization can be substantially reduced by aligning profiles up to the cleavage site positions of s...
Man-Wai Mak, Wei Wang, Sun-Yuan Kung