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» Approximation Algorithms for Optimal RNA Secondary Structure...
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GCB
2008
Springer
174views Biometrics» more  GCB 2008»
13 years 9 months ago
Lightweight Comparison of RNAs based on Exact Sequence-structure Matches
: Specific functions of RNA molecules are often associated with different motifs in the RNA structure. The key feature that forms such an RNA motif is the combination of sequence ...
Steffen Heyne, Sebastian Will, Michael Beckstette,...
BMCBI
2008
123views more  BMCBI 2008»
13 years 8 months ago
Shape based indexing for faster search of RNA family databases
Background: Most non-coding RNA families exert their function by means of a conserved, common secondary structure. The Rfam data base contains more than five hundred structurally ...
Stefan Janssen, Jens Reeder, Robert Giegerich
BMCBI
2008
109views more  BMCBI 2008»
13 years 8 months ago
ConStruct: Improved construction of RNA consensus structures
Background: Aligning homologous non-coding RNAs (ncRNAs) correctly in terms of sequence and structure is an unresolved problem, due to both mathematical complexity and imperfect s...
Andreas Wilm, Kornelia Linnenbrink, Gerhard Steger
BMCBI
2010
154views more  BMCBI 2010»
13 years 8 months ago
Fine-tuning structural RNA alignments in the twilight zone
Background: A widely used method to find conserved secondary structure in RNA is to first construct a multiple sequence alignment, and then fold the alignment, optimizing a score ...
Andreas Bremges, Stefanie Schirmer, Robert Giegeri...
CORR
2006
Springer
159views Education» more  CORR 2006»
13 years 7 months ago
Structural Alignments of pseudo-knotted RNA-molecules in polynomial time
An RNA molecule is structured on several layers. The primary and most obvious structure is its sequence of bases, i.e. a word over the alphabet {A, C, G, U}. The higher structure i...
Michael Brinkmeier