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NIPS
2004
13 years 8 months ago
Hierarchical Eigensolver for Transition Matrices in Spectral Methods
We show how to build hierarchical, reduced-rank representation for large stochastic matrices and use this representation to design an efficient algorithm for computing the largest...
Chakra Chennubhotla, Allan D. Jepson
BMCBI
2010
135views more  BMCBI 2010»
13 years 7 months ago
Delineation of amplification, hybridization and location effects in microarray data yields better-quality normalization
Background: Oligonucleotide arrays have become one of the most widely used high-throughput tools in biology. Due to their sensitivity to experimental conditions, normalization is ...
Marc Hulsman, Anouk Mentink, Eugene P. van Someren...
BMCBI
2010
126views more  BMCBI 2010»
13 years 7 months ago
Antisense DNA parameters derived from next-nearest-neighbor analysis of experimental data
Background: The enumeration of tetrameric and other sequence motifs that are positively or negatively correlated with in vivo antisense DNA effects has been a useful addition to t...
Donald M. Gray, Carla W. Gray, Byong-Hoon Yoo, Tzu...
BMCBI
2010
130views more  BMCBI 2010»
13 years 7 months ago
Amino acid "little Big Bang": Representing amino acid substitution matrices as dot products of Euclidian vectors
Background: Sequence comparisons make use of a one-letter representation for amino acids, the necessary quantitative information being supplied by the substitution matrices. This ...
Karel Zimmermann, Jean-François Gibrat
BMCBI
2008
242views more  BMCBI 2008»
13 years 7 months ago
New time-scale criteria for model simplification of bio-reaction systems
Background: Quasi-steady state approximation (QSSA) based on time-scale analysis is known to be an effective method for simplifying metabolic reaction system, but the conventional...
Junwon Choi, Kyung-won Yang, Tai-yong Lee, Sang Yu...