Background: With the exponential increase in genomic sequence data there is a need to develop automated approaches to deducing the biological functions of novel sequences with hig...
Background: The function of a novel gene product is typically predicted by transitive assignment of annotation from similar sequences. We describe a novel method, GOtcha, for pred...
David M. A. Martin, Matthew Berriman, Geoffrey J. ...
Background: Automated comparison of complete sets of genes encoded in two genomes can provide insight on the genetic basis of differences in biological traits between species. Gen...
Background: Gene Ontology (GO) annotation, which describes the function of genes and gene products across species, has recently been used to predict protein subcellular and subnuc...
The Gene Ontology (GO) is a controlled vocabulary of terms to describe protein functions. It also includes a hierarchical description of the relationships among the terms in the f...