Background: Second generation sequencing technologies yield DNA sequence data at ultra high-throughput. Common to most biological applications is a mapping of the reads to an almo...
Manuel Holtgrewe, Anne-Katrin Emde, David Weese, K...
Background: Many bioinformatics analyses, ranging from gene clustering to phylogenetics, produce hierarchical trees as their main result. These are used to represent the relations...
Background: A common approach to understanding the genetic basis of complex traits is through identification of associated quantitative trait loci (QTL). Fine mapping QTLs require...
Lukas A. Mueller, Adri A. Mills, Beth Skwarecki, R...
—The post-genomic era is characterized by the rapid data accumulation leading to unwieldy and large volumes of biological data. The proteomics results (large sets of identified p...
Eugenia G. Giannopoulou, Giorgos Lepouras, Elias S...
We introduce a model of DNA sequence evolution which can account for biases in mutation rates that depend on the identity of the neighboring bases. An analytic solution for this c...