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BMCBI
2006
110views more  BMCBI 2006»
13 years 8 months ago
Bias in error estimation when using cross-validation for model selection
Background: Cross-validation (CV) is an effective method for estimating the prediction error of a classifier. Some recent articles have proposed methods for optimizing classifiers...
Sudhir Varma, Richard Simon
BMCBI
2006
108views more  BMCBI 2006»
13 years 8 months ago
Promoter prediction and annotation of microbial genomes based on DNA sequence and structural responses to superhelical stress
Background: In our previous studies, we found that the sites in prokaryotic genomes which are most susceptible to duplex destabilization under the negative superhelical stresses t...
Huiquan Wang, Craig J. Benham
BMCBI
2006
133views more  BMCBI 2006»
13 years 8 months ago
Choosing negative examples for the prediction of protein-protein interactions
The protein-protein interaction networks of even well-studied model organisms are sketchy at best, highlighting the continued need for computational methods to help direct experim...
Asa Ben-Hur, William Stafford Noble
BMCBI
2006
242views more  BMCBI 2006»
13 years 8 months ago
Predicting residue-wise contact orders in proteins by support vector regression
Background: The residue-wise contact order (RWCO) describes the sequence separations between the residues of interest and its contacting residues in a protein sequence. It is a ne...
Jiangning Song, Kevin Burrage
BMCBI
2006
107views more  BMCBI 2006»
13 years 8 months ago
Analysis of optimal phenotypic space using elementary modes as applied to Corynebacterium glutamicum
Background: Quantification of the metabolic network of an organism offers insights into possible ways of developing mutant strain for better productivity of an extracellular metab...
Kalyan Gayen, K. V. Venkatesh