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BMCBI
2006
108views more  BMCBI 2006»
13 years 10 months ago
A new pooling strategy for high-throughput screening: the Shifted Transversal Design
Background: In binary high-throughput screening projects where the goal is the identification of low-frequency events, beyond the obvious issue of efficiency, false positives and ...
Nicolas Thierry-Mieg
BMCBI
2006
137views more  BMCBI 2006»
13 years 10 months ago
A classification-based framework for predicting and analyzing gene regulatory response
Background: We have recently introduced a predictive framework for studying gene transcriptional regulation in simpler organisms using a novel supervised learning algorithm called...
Anshul Kundaje, Manuel Middendorf, Mihir Shah, Chr...
BMCBI
2006
157views more  BMCBI 2006»
13 years 10 months ago
Determination of the minimum number of microarray experiments for discovery of gene expression patterns
Background: One type of DNA microarray experiment is discovery of gene expression patterns for a cell line undergoing a biological process over a series of time points. Two import...
Fang-Xiang Wu, W. J. Zhang, Anthony J. Kusalik
BMCBI
2006
126views more  BMCBI 2006»
13 years 10 months ago
Genomes as geography: using GIS technology to build interactive genome feature maps
Background: Many commonly used genome browsers display sequence annotations and related attributes as horizontal data tracks that can be toggled on and off according to user prefe...
Mary E. Dolan, Constance C. Holden, M. Kate Beard,...
BMCBI
2006
84views more  BMCBI 2006»
13 years 10 months ago
Inferring topology from clustering coefficients in protein-protein interaction networks
Background: Although protein-protein interaction networks determined with high-throughput methods are incomplete, they are commonly used to infer the topology of the complete inte...
Caroline C. Friedel, Ralf Zimmer