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BMCBI
2011
12 years 11 months ago
Combinatorial analysis and algorithms for quasispecies reconstruction using next-generation sequencing
Background: Next-generation sequencing (NGS) offers a unique opportunity for high-throughput genomics and has potential to replace Sanger sequencing in many fields, including de-n...
Mattia C. F. Prosperi, Luciano Prosperi, Alessandr...
BMCBI
2011
12 years 11 months ago
A hierarchical Bayesian network approach for linkage disequilibrium modeling and data-dimensionality reduction prior to genome-w
Background: Discovering the genetic basis of common genetic diseases in the human genome represents a public health issue. However, the dimensionality of the genetic data (up to 1...
Raphael Mourad, Christine Sinoquet, Philippe Leray
BMCBI
2011
12 years 11 months ago
Clustering gene expression data with a penalized graph-based metric
Background: The search for cluster structure in microarray datasets is a base problem for the so-called “-omic sciences”. A difficult problem in clustering is how to handle da...
Ariel E. Bayá, Pablo M. Granitto
BMCBI
2011
12 years 11 months ago
Robust joint analysis allowing for model uncertainty in two-stage genetic association studies
Background: The cost efficient two-stage design is often used in genome-wide association studies (GWASs) in searching for genetic loci underlying the susceptibility for complex di...
Dongdong Pan, Qizhai Li, Ningning Jiang, Aiyi Liu,...
BMCBI
2011
12 years 11 months ago
CLOTU: An online pipeline for processing and clustering of 454 amplicon reads into OTUs followed by taxonomic annotation
Background: The implementation of high throughput sequencing for exploring biodiversity poses high demands on bioinformatics applications for automated data processing. Here we in...
Surendra Kumar, Tor Carlsen, Bjørn-Helge Me...