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» Can we Find Molecular Signatures from Gene Expression Data
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BMCBI
2005
107views more  BMCBI 2005»
13 years 8 months ago
A stepwise framework for the normalization of array CGH data
Background: In two-channel competitive genomic hybridization microarray experiments, the ratio of the two fluorescent signal intensities at each spot on the microarray is commonly...
Mehrnoush Khojasteh, Wan L. Lam, Rabab Kreidieh Wa...
BMCBI
2005
112views more  BMCBI 2005»
13 years 8 months ago
"Harshlighting" small blemishes on microarrays
Background: Microscopists are familiar with many blemishes that fluorescence images can have due to dust and debris, glass flaws, uneven distribution of fluids or surface coatings...
Mayte Suárez-Fariñas, Asifa Haider, ...
BMCBI
2011
13 years 3 months ago
Sequential Interim Analyses of Survival Data in DNA Microarray Experiments
Background: Discovery of biomarkers that are correlated with therapy response and thus with survival is an important goal of medical research on severe diseases, e.g. cancer. Freq...
Andreas Leha, Tim Beißbarth, Klaus Jung
BMCBI
2010
187views more  BMCBI 2010»
13 years 8 months ago
PathEx: a novel multi factors based datasets selector web tool
Background: Microarray experiments have become very popular in life science research. However, if such experiments are only considered independently, the possibilities for analysi...
Eric Bareke, Michael Pierre, Anthoula Gaigneaux, B...
BMCBI
2010
165views more  BMCBI 2010»
13 years 8 months ago
Filtering, FDR and power
Background: In high-dimensional data analysis such as differential gene expression analysis, people often use filtering methods like fold-change or variance filters in an attempt ...
Maarten van Iterson, Judith M. Boer, Renée ...