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» Challenges of component-based development
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BMCBI
2010
141views more  BMCBI 2010»
15 years 2 months ago
Computing and visually analyzing mutual information in molecular co-evolution
Background: Selective pressure in molecular evolution leads to uneven distributions of amino acids and nucleotides. In fact one observes correlations among such constituents due t...
Sebastian Bremm, Tobias Schreck, Patrick Boba, Ste...
BMCBI
2010
162views more  BMCBI 2010»
15 years 2 months ago
SNP-RFLPing 2: an updated and integrated PCR-RFLP tool for SNP genotyping
Background: PCR-restriction fragment length polymorphism (RFLP) assay is a cost-effective method for SNP genotyping and mutation detection, but the manual mining for restriction e...
Hsueh-Wei Chang, Yu-Huei Cheng, Li-Yeh Chuang, Che...
125
Voted
BMCBI
2010
152views more  BMCBI 2010»
15 years 2 months ago
Apples and oranges: avoiding different priors in Bayesian DNA sequence analysis
Background: One of the challenges of bioinformatics remains the recognition of short signal sequences in genomic DNA such as donor or acceptor splice sites, splicing enhancers or ...
Jens Keilwagen, Jan Grau, Stefan Posch, Ivo Grosse
BMCBI
2010
183views more  BMCBI 2010»
15 years 2 months ago
SOPRA: Scaffolding algorithm for paired reads via statistical optimization
Background: High throughput sequencing (HTS) platforms produce gigabases of short read (<100 bp) data per run. While these short reads are adequate for resequencing application...
Adel Dayarian, Todd P. Michael, Anirvan M. Sengupt...
BMCBI
2010
93views more  BMCBI 2010»
15 years 2 months ago
HAT: Hypergeometric Analysis of Tiling-arrays with application to promoter-GeneChip data
Background: Tiling-arrays are applicable to multiple types of biological research questions. Due to its advantages (high sensitivity, resolution, unbiased), the technology is ofte...
Erdogan Taskesen, Renee Beekman, Jeroen de Ridder,...