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» Clustered Sequence Representation for Fast Homology Search
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BMCBI
2010
121views more  BMCBI 2010»
13 years 7 months ago
Knowledge-based annotation of small molecule binding sites in proteins
Background: The study of protein-small molecule interactions is vital for understanding protein function and for practical applications in drug discovery. To benefit from the rapi...
Ratna R. Thangudu, Manoj Tyagi, Benjamin A. Shoema...
BMCBI
2005
97views more  BMCBI 2005»
13 years 7 months ago
Clustering the annotation space of proteins
Background: Current protein clustering methods rely on either sequence or functional similarities between proteins, thereby limiting inferences to one of these areas. Results: Her...
Victor Kunin, Christos A. Ouzounis
BMCBI
2006
92views more  BMCBI 2006»
13 years 7 months ago
Similarity-based gene detection: using COGs to find evolutionarily-conserved ORFs
Background: Experimental verification of gene products has not kept pace with the rapid growth of microbial sequence information. However, existing annotations of gene locations c...
Bradford C. Powell, Clyde A. Hutchison III
CEC
2005
IEEE
14 years 1 months ago
Fast evolution of custom machine representations
Described are new approaches for evaluating computer program representations for use in automated search methodologies such as the evolutionary design of software. Previously, prog...
Lorenz Huelsbergen
BMCBI
2006
112views more  BMCBI 2006»
13 years 7 months ago
A phylogenomic gene cluster resource: the Phylogenetically Inferred Groups (PhIGs) database
Background: We present here the PhIGs database, a phylogenomic resource for sequenced genomes. Although many methods exist for clustering gene families, very few attempt to create...
Paramvir S. Dehal, Jeffrey L. Boore