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137
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BMCBI
2010
104views more  BMCBI 2010»
15 years 3 months ago
A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-or
Background: G protein-coupled receptors (GPCRs) represent a family of well-characterized drug targets with significant therapeutic value. Phylogenetic classifications may help to ...
Eelke van der Horst, Julio E. Peironcely, Adriaan ...
142
Voted
BMCBI
2010
139views more  BMCBI 2010»
15 years 3 months ago
A global optimization algorithm for protein surface alignment
Background: A relevant problem in drug design is the comparison and recognition of protein binding sites. Binding sites recognition is generally based on geometry often combined w...
Paola Bertolazzi, Concettina Guerra, Giampaolo Liu...
141
Voted
BMCBI
2010
198views more  BMCBI 2010»
15 years 3 months ago
ClustalXeed: a GUI-based grid computation version for high performance and terabyte size multiple sequence alignment
Background: There is an increasing demand to assemble and align large-scale biological sequence data sets. The commonly used multiple sequence alignment programs are still limited...
Taeho Kim, Hyun Joo
BMCBI
2008
146views more  BMCBI 2008»
15 years 3 months ago
Can molecular dynamics simulations help in discriminating correct from erroneous protein 3D models?
Background: Recent approaches for predicting the three-dimensional (3D) structure of proteins such as de novo or fold recognition methods mostly rely on simplified energy potentia...
Jean-François Taly, Antoine Marin, Jean-Fra...
CORR
2008
Springer
107views Education» more  CORR 2008»
15 years 3 months ago
Our Brothers' Keepers: Secure Routing with High Performance
The Trinity [1] spam classification system is based on a distributed hash table that is implemented using a structured peer-to-peer overlay. Such an overlay must be capable of proc...
Alex Brodsky, Scott Lindenberg