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» Clustering the annotation space of proteins
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BIBE
2005
IEEE
115views Bioinformatics» more  BIBE 2005»
14 years 3 months ago
GOMIT: A Generic and Adaptive Annotation Algorithm Based on Gene Ontology Term Distributions
We address the issue of providing highly informative annotations using information revealed by the structured vocabularies of Gene Ontology (GO). For a target, a set of candidate ...
In-Yee Lee, Jan-Ming Ho, Ming-Syan Chen
BMCBI
2008
130views more  BMCBI 2008»
13 years 10 months ago
A novel series of compositionally biased substitution matrices for comparing Plasmodium proteins
Background: The most common substitution matrices currently used (BLOSUM and PAM) are based on protein sequences with average amino acid distributions, thus they do not represent ...
Kevin Brick, Elisabetta Pizzi
BIBM
2010
IEEE
157views Bioinformatics» more  BIBM 2010»
13 years 8 months ago
Decomposing PPI networks for complex discovery
Abstract--Protein complexes are important for understanding principles of cellular organization and functions. With the availability of large amounts of high-throughput proteinprot...
Guimei Liu, Chern Han Yong, Limsoon Wong, Hon Nian...
IHI
2012
370views Healthcare» more  IHI 2012»
12 years 5 months ago
FUSE: a system for data-driven multi-level functional summarization of protein interaction networks
Despite recent progress in high-throughput experimental studies, systems level visualization and analysis of large protein interaction networks (ppi) remains a challenging task, g...
Boon-Siew Seah, Sourav S. Bhowmick, Charles Forbes...
BMCBI
2010
163views more  BMCBI 2010»
13 years 10 months ago
Reduced representation of protein structure: implications on efficiency and scope of detection of structural similarity
Background: Computational comparison of two protein structures is the starting point of many methods that build on existing knowledge, such as structure modeling (including modeli...
Zong Hong Zhang, Hwee Kuan Lee, Ivana Mihalek