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BIODATAMINING
2008
13 years 9 months ago
2008
Background: Dysfunction in the endolysosome, a late endosomal to lysosomal degradative intracellular compartment, is an early hallmark of some neurodegenerative diseases, in parti...
BIODATAMINING
2008
13 years 9 months ago
2008
Background: Contrary to the traditional biology approach, where the expression patterns of a handful of genes are studied at a time, microarray experiments enable biologists to st...
BMCBI
2010
13 years 9 months ago
2010
Background: Principal component analysis (PCA) has gained popularity as a method for the analysis of highdimensional genomic data. However, it is often difficult to interpret the ...
BMCBI
2010
13 years 9 months ago
2010
Background: Cancer and other disorders are due to genomic lesions. SNP-microarrays are able to measure simultaneously both genotype and copy number (CN) at several Single Nucleoti...
BMCBI
2010
13 years 9 months ago
2010
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...