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IJON
2010
148views more  IJON 2010»
13 years 4 months ago
Integration of heterogeneous data sources for gene function prediction using decision templates and ensembles of learning machin
Several solutions have been proposed to exploit the availability of heterogeneous sources of biomolecular data for gene function prediction, but few attention has been dedicated t...
Matteo Re, Giorgio Valentini
BMCBI
2008
118views more  BMCBI 2008»
13 years 7 months ago
Evaluation of phylogenetic footprint discovery for predicting bacterial cis-regulatory elements and revealing their evolution
Background: The detection of conserved motifs in promoters of orthologous genes (phylogenetic footprints) has become a common strategy to predict cis-acting regulatory elements. S...
Rekin's Janky, Jacques van Helden
BMCBI
2006
120views more  BMCBI 2006»
13 years 7 months ago
A factor analysis model for functional genomics
Background: Expression array data are used to predict biological functions of uncharacterized genes by comparing their expression profiles to those of characterized genes. While b...
Rafal Kustra, Romy Shioda, Mu Zhu
BMCBI
2008
80views more  BMCBI 2008»
13 years 7 months ago
Computational evaluation of TIS annotation for prokaryotic genomes
Background: Accurate annotation of translation initiation sites (TISs) is essential for understanding the translation initiation mechanism. However, the reliability of TIS annotat...
Gang-Qing Hu, Xiaobin Zheng, Li-Ning Ju, Huaiqiu Z...
BMCBI
2006
119views more  BMCBI 2006»
13 years 7 months ago
LS-NMF: A modified non-negative matrix factorization algorithm utilizing uncertainty estimates
Background: Non-negative matrix factorisation (NMF), a machine learning algorithm, has been applied to the analysis of microarray data. A key feature of NMF is the ability to iden...
Guoli Wang, Andrew V. Kossenkov, Michael F. Ochs