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BMCBI
2005
116views more  BMCBI 2005»
13 years 9 months ago
Can Zipf's law be adapted to normalize microarrays?
Background: Normalization is the process of removing non-biological sources of variation between array experiments. Recent investigations of data in gene expression databases for ...
Timothy Lu, Christine M. Costello, Peter J. P. Cro...
ICML
2010
IEEE
13 years 7 months ago
Heterogeneous Continuous Dynamic Bayesian Networks with Flexible Structure and Inter-Time Segment Information Sharing
Classical dynamic Bayesian networks (DBNs) are based on the homogeneous Markov assumption and cannot deal with heterogeneity and non-stationarity in temporal processes. Various ap...
Frank Dondelinger, Sophie Lebre, Dirk Husmeier
GCB
2008
Springer
103views Biometrics» more  GCB 2008»
13 years 10 months ago
Utilizing Promoter Pair Orientations for HMM-based Analysis of ChIP-chip Data
: Array-based analysis of chromatin immunoprecipitation data (ChIP-chip) is a powerful technique for identifying DNA target regions of individual transcription factors. Here, we pr...
Michael Seifert, Jens Keilwagen, Marc Strickert, I...
BMCBI
2008
121views more  BMCBI 2008»
13 years 9 months ago
Stability of gene contributions and identification of outliers in multivariate analysis of microarray data
Background: Multivariate ordination methods are powerful tools for the exploration of complex data structures present in microarray data. These methods have several advantages com...
Florent Baty, Daniel Jaeger, Frank Preiswerk, Mart...
BMCBI
2010
178views more  BMCBI 2010»
13 years 9 months ago
An improved method for scoring protein-protein interactions using semantic similarity within the Gene Ontology
Background: Semantic similarity measures are useful to assess the physiological relevance of protein-protein interactions (PPIs). They quantify similarity between proteins based o...
Shobhit Jain, Gary D. Bader