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BMCBI
2010
116views more  BMCBI 2010»
13 years 8 months ago
Optimization algorithms for functional deimmunization of therapeutic proteins
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...
Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chr...
BMCBI
2010
112views more  BMCBI 2010»
13 years 8 months ago
Knowledge-based analysis of microarrays for the discovery of transcriptional regulation relationships
Background: The large amount of high-throughput genomic data has facilitated the discovery of the regulatory relationships between transcription factors and their target genes. Wh...
Junhee Seok, Amit Kaushal, Ronald W. Davis, Wenzho...
BMCBI
2011
13 years 3 months ago
OrthoInspector: comprehensive orthology analysis and visual exploration
Background: The accurate determination of orthology and inparalogy relationships is essential for comparative sequence analysis, functional gene annotation and evolutionary studie...
Benjamin Linard, Julie D. Thompson, Olivier Poch, ...
ESANN
2000
13 years 10 months ago
Distributed clustering and local regression for knowledge discovery in multiple spatial databases
Many large -scale spatial data analysis problems involve an investigation of relationships in heterogeneous databases. In such situations, instead of making predictions uniformly a...
Aleksandar Lazarevic, Dragoljub Pokrajac, Zoran Ob...
BMCBI
2011
13 years 9 days ago
Elastic SCAD as a novel penalization method for SVM classification tasks in high-dimensional data
Background: Classification and variable selection play an important role in knowledge discovery in highdimensional data. Although Support Vector Machine (SVM) algorithms are among...
Natalia Becker, Grischa Toedt, Peter Lichter, Axel...