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BMCBI
2010
154views more  BMCBI 2010»
13 years 10 months ago
Binary image representation of a ligand binding site: its application to efficient sampling of a conformational ensemble
Background: Modelling the ligand binding site of a protein is an important component of understanding proteinligand interactions and is being actively studied. Even if the side ch...
Edon Sung, Sangsoo Kim, Whanchul Shin
BMCBI
2010
102views more  BMCBI 2010»
13 years 10 months ago
Alignment and clustering of phylogenetic markers - implications for microbial diversity studies
Background: Molecular studies of microbial diversity have provided many insights into the bacterial communities inhabiting the human body and the environment. A common first step ...
James Robert White, Saket Navlakha, Niranjan Nagar...
BMCBI
2010
118views more  BMCBI 2010»
13 years 10 months ago
Detecting lateral gene transfers by statistical reconciliation of phylogenetic forests
Background: To understand the evolutionary role of Lateral Gene Transfer (LGT), accurate methods are needed to identify transferred genes and infer their timing of acquisition. Ph...
Sophie S. Abby, Eric Tannier, Manolo Gouy, Vincent...
BMCBI
2010
100views more  BMCBI 2010»
13 years 10 months ago
Partitioning of copy-number genotypes in pedigrees
Background: Copy number variations (CNVs) and polymorphisms (CNPs) have only recently gained the genetic community's attention. Conservative estimates have shown that CNVs an...
Louis-Philippe Lemieux Perreault, Gregor U. Andelf...
BMCBI
2010
118views more  BMCBI 2010»
13 years 10 months ago
Computing H/D-Exchange rates of single residues from data of proteolytic fragments
Background: Protein conformation and protein/protein interaction can be elucidated by solution-phase Hydrogen/ Deuterium exchange (sHDX) coupled to high-resolution mass analysis o...
Ernst Althaus, Stefan Canzar, Carsten Ehrler, Mark...
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