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BMCBI
2010
103views more  BMCBI 2010»
13 years 7 months ago
A method of predicting changes in human gene splicing induced by genetic variants in context of cis-acting elements
Background: Polymorphic variants and mutations disrupting canonical splicing isoforms are among the leading causes of human hereditary disorders. While there is a substantial evid...
Alexander G. Churbanov, Igor Vorechovsky, Chindo H...
BMCBI
2010
114views more  BMCBI 2010»
13 years 7 months ago
An integrative modular approach to systematically predict gene-phenotype associations
Background: Complex human diseases are often caused by multiple mutations, each of which contributes only a minor effect to the disease phenotype. To study the basis for these com...
Michael R. Mehan, Juan Nunez-Iglesias, Chao Dai, M...
IJBRA
2007
120views more  IJBRA 2007»
13 years 7 months ago
The myGrid ontology: bioinformatics service discovery
: In this paper we explore issues in the development of the my Grid ontology, which is an OWL ontology designed to support service discovery through service annotation. There are c...
Katy Wolstencroft, Pinar Alper, Duncan Hull, Chris...
BMCBI
2005
110views more  BMCBI 2005»
13 years 7 months ago
ProGenExpress: Visualization of quantitative data on prokaryotic genomes
Background: The integration of genomic information with quantitative experimental data is a key component of systems biology. An increasing number of microbial genomes are being s...
Michael Watson
JKM
2007
213views more  JKM 2007»
13 years 7 months ago
A systems-based dynamic knowledge transfer capacity model
Purpose – The purpose of this paper is twofold: to understand how recent developments in systems thinking and social construction can influence understanding of knowledge trans...
Robert Parent, Mario Roy, Denis St-Jacques