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» Compressing Genomic Sequence Fragments Using SlimGene
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BMCBI
2004
96views more  BMCBI 2004»
13 years 7 months ago
Identification of regions in multiple sequence alignments thermodynamically suitable for targeting by consensus oligonucleotides
Background: Computer programs for the generation of multiple sequence alignments such as "Clustal W" allow detection of regions that are most conserved among many sequen...
Olga V. Matveeva, Brian T. Foley, Vladimir A. Nemt...
BMCBI
2011
12 years 11 months ago
Combinatorial analysis and algorithms for quasispecies reconstruction using next-generation sequencing
Background: Next-generation sequencing (NGS) offers a unique opportunity for high-throughput genomics and has potential to replace Sanger sequencing in many fields, including de-n...
Mattia C. F. Prosperi, Luciano Prosperi, Alessandr...
BMCBI
2010
132views more  BMCBI 2010»
13 years 7 months ago
Data structures and compression algorithms for high-throughput sequencing technologies
Background: High-throughput sequencing (HTS) technologies play important roles in the life sciences by allowing the rapid parallel sequencing of very large numbers of relatively s...
Kenny Daily, Paul Rigor, Scott Christley, Xiaohui ...
BMCBI
2008
108views more  BMCBI 2008»
13 years 7 months ago
Supervised Lowess normalization of comparative genome hybridization data - application to lactococcal strain comparisons
Background: Array-based comparative genome hybridization (aCGH) is commonly used to determine the genomic content of bacterial strains. Since prokaryotes in general have less cons...
Sacha A. F. T. van Hijum, Richard J. S. Baerends, ...
CDB
2004
Springer
172views Database» more  CDB 2004»
14 years 24 days ago
Constraint Database Solutions to the Genome Map Assembly Problem
Abstract. Long DNA sequences have to be cut using restriction enzymes into small fragments whose lengths and/or nucleotide sequences can be analyzed by currently available technolo...
Viswanathan Ramanathan, Peter Z. Revesz