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RECOMB
2010
Springer
14 years 3 months ago
Genomic DNA k-mer Spectra: Models and Modalities
Background: The empirical frequencies of DNA k-mers in whole genome sequences provide an interesting perspective on genomic complexity, and the availability of large segments of g...
Benny Chor, David Horn, Nick Goldman, Yaron Levy, ...
ISMB
1993
13 years 10 months ago
Discovering Sequence Similarity by the Algorithmic Significance Method
The minimal-length encoding approach is applied to define concept of sequence similarity. Asequence is defined to be similar to another sequence or to a set of keywords if it can ...
Aleksandar Milosavljevic
AC
2004
Springer
13 years 8 months ago
Shotgun Sequence Assembly
Shotgun sequencing is the most widely used technique for determining the DNA sequence of organisms. It involves breaking up the DNA into many small pieces that can be read by auto...
Mihai Pop
BMCBI
2010
167views more  BMCBI 2010»
13 years 8 months ago
Creating PWMs of transcription factors using 3D structure-based computation of protein-DNA free binding energies
Background: Knowledge of transcription factor-DNA binding patterns is crucial for understanding gene transcription. Numerous DNA-binding proteins are annotated as transcription fa...
Denitsa Alamanova, Philip Stegmaier, Alexander E. ...
BMCBI
2010
145views more  BMCBI 2010»
13 years 8 months ago
Clustering metagenomic sequences with interpolated Markov models
Background: Sequencing of environmental DNA (often called metagenomics) has shown tremendous potential to uncover the vast number of unknown microbes that cannot be cultured and s...
David R. Kelley, Steven L. Salzberg