The accurate computational prediction of RNA secondary structures is a difficult task, but an important one, since RNA structure is usually more evolutionarily conserved than prima...
Background: Aligning homologous non-coding RNAs (ncRNAs) correctly in terms of sequence and structure is an unresolved problem, due to both mathematical complexity and imperfect s...
Andreas Wilm, Kornelia Linnenbrink, Gerhard Steger
Background: The identification of a consensus RNA motif often consists in finding a conserved secondary structure with minimum free energy in an ensemble of aligned sequences. How...
Background: Utilization of alternative initiation sites for protein translation directed by non-AUG codons in mammalian mRNAs is observed with increasing frequency. Alternative in...
Jill L. Wegrzyn, Thomas M. Drudge, Faramarz Valafa...
The history of molecular biology is punctuated by a series of discoveries demonstrating the surprising breadth of biological roles of ribonucleic acid (RNA). An ensemble of evoluti...