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BMCBI
2010
137views more  BMCBI 2010»
13 years 6 months ago
Improving pairwise sequence alignment accuracy using near-optimal protein sequence alignments
Background: While the pairwise alignments produced by sequence similarity searches are a powerful tool for identifying homologous proteins - proteins that share a common ancestor ...
Michael L. Sierk, Michael E. Smoot, Ellen J. Bass,...
BMCBI
2010
151views more  BMCBI 2010»
13 years 6 months ago
Classification of G-protein coupled receptors based on support vector machine with maximum relevance minimum redundancy and gene
Background: Because a priori knowledge about function of G protein-coupled receptors (GPCRs) can provide useful information to pharmaceutical research, the determination of their ...
Zhanchao Li, Xuan Zhou, Zong Dai, Xiaoyong Zou
BMCBI
2010
109views more  BMCBI 2010»
13 years 6 months ago
Pripper: prediction of caspase cleavage sites from whole proteomes
Background: Caspases are a family of proteases that have central functions in programmed cell death (apoptosis) and inflammation. Caspases mediate their effects through aspartate-...
Mirva Piippo, Niina Lietzén, Olli Nevalaine...
BMCBI
2010
109views more  BMCBI 2010»
13 years 6 months ago
Application of machine learning methods to histone methylation ChIP-Seq data reveals H4R3me2 globally represses gene expression
Background: In the last decade, biochemical studies have revealed that epigenetic modifications including histone modifications, histone variants and DNA methylation form a comple...
Xiaojiang Xu, Stephen Hoang, Marty W. Mayo, Stefan...
BMCBI
2010
240views more  BMCBI 2010»
13 years 6 months ago
CircuitsDB: a database of mixed microRNA/transcription factor feed-forward regulatory circuits in human and mouse
Background: Transcription Factors (TFs) and microRNAs (miRNAs) are key players for gene expression regulation in higher eukaryotes. In the last years, a large amount of bioinforma...
Olivier Friard, Angela Re, Daniela Taverna, Michel...