Background: Exhaustive methods of sequence alignment are accurate but slow, whereas heuristic approaches run quickly, but their complexity makes them more difficult to implement. ...
When aligning biological sequences, the choice of scoring scheme is critical. Even small changes in gap penalties, for example, can yield radically different alignments. A rigorous...
Computation of multiple sequence alignments is one of the major open problems in computational molecular biology. The purpose of this study was to provide a new method, PAC (Progre...