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120
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BMCBI
2010
115views more  BMCBI 2010»
15 years 3 months ago
CONAN: copy number variation analysis software for genome-wide association studies
Background: Genome-wide association studies (GWAS) based on single nucleotide polymorphisms (SNPs) revolutionized our perception of the genetic regulation of complex traits and di...
Lukas Forer, Sebastian Schönherr, Hansi Wei&s...
109
Voted
BMCBI
2010
107views more  BMCBI 2010»
15 years 3 months ago
Detection of characteristic sub pathway network for angiogenesis based on the comprehensive pathway network
Background: Pathways in biological system often cooperate with each other to function. Changes of interactions among pathways tightly associate with alterations in the properties ...
Yezhou Huang, Shao Li
114
Voted
BMCBI
2010
113views more  BMCBI 2010»
15 years 3 months ago
Efficient protein alignment algorithm for protein search
Background: Proteins show a great variety of 3D conformations, which can be used to infer their evolutionary relationship and to classify them into more general groups; therefore ...
Zaixin Lu, Zhiyu Zhao, Bin Fu
113
Voted
BMCBI
2010
132views more  BMCBI 2010»
15 years 3 months ago
Consistency, comprehensiveness, and compatibility of pathway databases
Background: It is necessary to analyze microarray experiments together with biological information to make better biological inferences. We investigate the adequacy of current bio...
Donny Soh, Difeng Dong, Yike Guo, Limsoon Wong
127
Voted
BMCBI
2010
154views more  BMCBI 2010»
15 years 3 months ago
An algorithm for automated closure during assembly
Background: Finishing is the process of improving the quality and utility of draft genome sequences generated by shotgun sequencing and computational assembly. Finishing can invol...
Sergey Koren, Jason R. Miller, Brian Walenz, Grang...