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BMCBI
2008
130views more  BMCBI 2008»
13 years 7 months ago
A database of phylogenetically atypical genes in archaeal and bacterial genomes, identified using the DarkHorse algorithm
Background: The process of horizontal gene transfer (HGT) is believed to be widespread in Bacteria and Archaea, but little comparative data is available addressing its occurrence ...
Sheila Podell, Terry Gaasterland, Eric E. Allen
BMCBI
2008
123views more  BMCBI 2008»
13 years 7 months ago
A tree-based conservation scoring method for short linear motifs in multiple alignments of protein sequences
Background: The structure of many eukaryotic cell regulatory proteins is highly modular. They are assembled from globular domains, segments of natively disordered polypeptides and...
Claudia Chica, Alberto Labarga, Cathryn M. Gould, ...
BMCBI
2005
100views more  BMCBI 2005»
13 years 7 months ago
Speeding disease gene discovery by sequence based candidate prioritization
Background: Regions of interest identified through genetic linkage studies regularly exceed 30 centimorgans in size and can contain hundreds of genes. Traditionally this number is...
Euan A. Adie, Richard R. Adams, Kathryn L. Evans, ...
BMCBI
2005
73views more  BMCBI 2005»
13 years 7 months ago
Evaluation of Glycine max mRNA clusters
Background: Clustering the ESTs from a large dataset representing a single species is a convenient starting point for a number of investigations into gene discovery, genome evolut...
Ronald L. Frank, Fikret Erçal
BMCBI
2004
150views more  BMCBI 2004»
13 years 7 months ago
Cross-species comparison significantly improves genome-wide prediction of cis-regulatory modules in Drosophila
Background: The discovery of cis-regulatory modules in metazoan genomes is crucial for understanding the connection between genes and organism diversity. It is important to quanti...
Saurabh Sinha, Mark D. Schroeder, Ulrich Unnerstal...