Background: Recent, rapid growth in the quantity of available genomic data has generated many protein sequences that are not yet biochemically classified. Thus, the prediction of ...
Computational analyses of protein structure-function relationships have traditionally been based on sequence homology, fold family analysis and 3D motifs/templates. Previous struct...
Reetal Pai, James C. Sacchettini, Thomas R. Ioerge...
We describe a new algorithm for protein classi cation and the detection of remote homologs. The rationale is to exploit both vertical and horizontal information of a multiple alig...
Background: We present a complete re-implementation of the segment-based approach to multiple protein alignment that contains a number of improvements compared to the previous ver...
Amarendran R. Subramanian, Jan Weyer-Menkhoff, Mic...
COMPASS is a method for homology detection and local alignment construction based on the comparison of multiple sequence alignments (MSAs). The method derives numerical profiles f...
Ruslan Sadreyev, Ming Tang, Bong-Hyun Kim, Nick V....