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» DNA Sequence Design Using Templates
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BMCBI
2010
128views more  BMCBI 2010»
13 years 7 months ago
MPprimer: a program for reliable multiplex PCR primer design
Background: Multiplex PCR, defined as the simultaneous amplification of multiple regions of a DNA template or multiple DNA templates using more than one primer set (comprising a f...
Zhiyong Shen, Wubin Qu, Wen Wang, Yiming Lu, Yongh...
WABI
2009
Springer
142views Bioinformatics» more  WABI 2009»
14 years 2 months ago
Back-Translation for Discovering Distant Protein Homologies
Background: Frameshift mutations in protein-coding DNA sequences produce a drastic change in the resulting protein sequence, which prevents classic protein alignment methods from ...
Marta Gîrdea, Laurent Noé, Gregory Ku...
BMCBI
2008
111views more  BMCBI 2008»
13 years 7 months ago
Aspects of coverage in medical DNA sequencing
Background: DNA sequencing is now emerging as an important component in biomedical studies of diseases like cancer. Short-read, highly parallel sequencing instruments are expected...
Michael C. Wendl, Richard K. Wilson
BMCBI
2006
117views more  BMCBI 2006»
13 years 7 months ago
Gene Designer: a synthetic biology tool for constructing artificial DNA segments
Background: Direct synthesis of genes is rapidly becoming the most efficient way to make functional genetic constructs and enables applications such as codon optimization, RNAi re...
Alan Villalobos, Jon E. Ness, Claes Gustafsson, Je...
BIB
2008
88views more  BIB 2008»
13 years 7 months ago
MEGA: A biologist-centric software for evolutionary analysis of DNA and protein sequences
The Molecular Evolutionary Genetics Analysis (MEGA) software is a desktop application designed for comparative analysis of homologous gene sequences either from multigene families...
Sudhir Kumar, Masatoshi Nei, Joel Dudley, Koichiro...