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BMCBI
2008
105views more  BMCBI 2008»
13 years 7 months ago
Novel computational methods for increasing PCR primer design effectiveness in directed sequencing
Background: Polymerase chain reaction (PCR) is used in directed sequencing for the discovery of novel polymorphisms. As the first step in PCR directed sequencing, effective PCR pr...
Kelvin Li, Anushka Brownley, Timothy B. Stockwell,...
BMCBI
2010
208views more  BMCBI 2010»
13 years 7 months ago
Calculation of accurate small angle X-ray scattering curves from coarse-grained protein models
Background: Genome sequencing projects have expanded the gap between the amount of known protein sequences and structures. The limitations of current high resolution structure det...
Kasper Stovgaard, Christian Andreetta, Jesper Ferk...
BMCBI
2008
158views more  BMCBI 2008»
13 years 7 months ago
Metrics for GO based protein semantic similarity: a systematic evaluation
Background: Several semantic similarity measures have been applied to gene products annotated with Gene Ontology terms, providing a basis for their functional comparison. However,...
Catia Pesquita, Daniel Faria, Hugo P. Bastos, Ant&...
CCR
2008
84views more  CCR 2008»
13 years 7 months ago
Modeling internet topology dynamics
Despite the large number of papers on network topology modeling and inference, there still exists ambiguity about the real nature of the Internet AS and router level topology. Whi...
Hamed Haddadi, Steve Uhlig, Andrew W. Moore, Richa...
CN
2008
80views more  CN 2008»
13 years 7 months ago
Practical large-scale latency estimation
We present the implementation of a large-scale latency estimation system based on GNP and incorporated into the Google content delivery network. Our implementation does not rely o...
Michal Szymaniak, David L. Presotto, Guillaume Pie...