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BMCBI
2010
108views more  BMCBI 2010»
13 years 11 months ago
An intuitionistic approach to scoring DNA sequences against transcription factor binding site motifs
Background: Transcription factors (TFs) control transcription by binding to specific regions of DNA called transcription factor binding sites (TFBSs). The identification of TFBSs ...
Fernando Garcia-Alcalde, Armando Blanco, Adrian J....
BMCBI
2008
139views more  BMCBI 2008»
13 years 11 months ago
The C1C2: A framework for simultaneous model selection and assessment
Background: There has been recent concern regarding the inability of predictive modeling approaches to generalize to new data. Some of the problems can be attributed to improper m...
Martin Eklund, Ola Spjuth, Jarl E. S. Wikberg
BMCBI
2008
123views more  BMCBI 2008»
13 years 11 months ago
Validation of protein models by a neural network approach
Background: The development and improvement of reliable computational methods designed to evaluate the quality of protein models is relevant in the context of protein structure re...
Paolo Mereghetti, Maria Luisa Ganadu, Elena Papale...
BMCBI
2008
132views more  BMCBI 2008»
13 years 11 months ago
Clustering ionic flow blockade toggles with a Mixture of HMMs
Background: Ionic current blockade signal processing, for use in nanopore detection, offers a promising new way to analyze single molecule properties with potential implications f...
Alexander G. Churbanov, Stephen Winters-Hilt
BMCBI
2008
102views more  BMCBI 2008»
13 years 11 months ago
Fast splice site detection using information content and feature reduction
Background: Accurate identification of splice sites in DNA sequences plays a key role in the prediction of gene structure in eukaryotes. Already many computational methods have be...
A. K. M. A. Baten, Saman K. Halgamuge, Bill C. H. ...