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BMCBI
2008
144views more  BMCBI 2008»
13 years 7 months ago
Local conservation scores without a priori assumptions on neutral substitution rates
Background: Comparative genomics aims to detect signals of evolutionary conservation as an indicator of functional constraint. Surprisingly, results of the ENCODE project revealed...
Janis Dingel, Pavol Hanus, Niccolò Leonardi...
SIGIR
2008
ACM
13 years 7 months ago
Optimizing relevance and revenue in ad search: a query substitution approach
The primary business model behind Web search is based on textual advertising, where contextually relevant ads are displayed alongside search results. We address the problem of sel...
Filip Radlinski, Andrei Z. Broder, Peter Ciccolo, ...
SIGECOM
2003
ACM
124views ECommerce» more  SIGECOM 2003»
14 years 24 days ago
Coalitional games on graphs: core structure, substitutes and frugality
We study mechanisms that can be modelled as coalitional games with transferable utilities, and apply ideas from mechanism design and game theory to problems arising in a network d...
Rahul Garg, Vijay Kumar, Atri Rudra, Akshat Verma
JCB
2002
74views more  JCB 2002»
13 years 7 months ago
Using Substitution Matrices to Estimate Probability Distributions for Biological Sequences
Accurately estimating probabilities from observations is important for probabilistic-based approaches to problems in computational biology. In this paper we present a biologically...
Eleazar Eskin, William Stafford Noble, Yoram Singe...
CANDC
2007
ACM
13 years 7 months ago
Codon phylogenetic distance
We develop here an analytical evolution model based on a trinucleotide mutation matrix 64 × 64 with nine substitution parameters associated with the three types of substitutions ...
Christian J. Michel