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BIOINFORMATICS
2008
172views more  BIOINFORMATICS 2008»
13 years 10 months ago
Fitting a geometric graph to a protein-protein interaction network
Motivation: Finding a good network null model for protein-protein interaction (PPI) networks is a fundamental issue. Such a model would provide insights into the interplay between...
Desmond J. Higham, Marija Rasajski, Natasa Przulj
BMCBI
2010
87views more  BMCBI 2010»
13 years 10 months ago
poolMC: Smart pooling of mRNA samples in microarray experiments
Background: Typically, pooling of mRNA samples in microarray experiments implies mixing mRNA from several biological-replicate samples before hybridization onto a microarray chip....
Raghunandan M. Kainkaryam, Angela Bruex, Anna C. G...
BMCBI
2010
165views more  BMCBI 2010»
13 years 10 months ago
Bayesian integrated modeling of expression data: a case study on RhoG
Background: DNA microarrays provide an efficient method for measuring activity of genes in parallel and even covering all the known transcripts of an organism on a single array. T...
Rashi Gupta, Dario Greco, Petri Auvinen, Elja Arja...
BMCBI
2010
156views more  BMCBI 2010»
13 years 10 months ago
Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments
Background: High-throughput sequencing technologies, such as the Illumina Genome Analyzer, are powerful new tools for investigating a wide range of biological and medical question...
James H. Bullard, Elizabeth Purdom, Kasper D. Hans...
BMCBI
2010
116views more  BMCBI 2010»
13 years 10 months ago
FiGS: a filter-based gene selection workbench for microarray data
Background: The selection of genes that discriminate disease classes from microarray data is widely used for the identification of diagnostic biomarkers. Although various gene sel...
Taeho Hwang, Choong-Hyun Sun, Taegyun Yun, Gwan-Su...