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BMCBI
2006
147views more  BMCBI 2006»
13 years 7 months ago
A case study in pathway knowledgebase verification
Background: Biological databases and pathway knowledgebases are proliferating rapidly. We are developing software tools for computer-aided hypothesis design and evaluation, and we...
Stephen A. Racunas, Nigam Shah, Nina V. Fedoroff
BMCBI
2006
180views more  BMCBI 2006»
13 years 7 months ago
The Gaggle: An open-source software system for integrating bioinformatics software and data sources
Background: Systems biologists work with many kinds of data, from many different sources, using a variety of software tools. Each of these tools typically excels at one type of an...
Paul T. Shannon, David J. Reiss, Richard Bonneau, ...
BMCBI
2006
156views more  BMCBI 2006»
13 years 7 months ago
Score-based prediction of genomic islands in prokaryotic genomes using hidden Markov models
Background: Horizontal gene transfer (HGT) is considered a strong evolutionary force shaping the content of microbial genomes in a substantial manner. It is the difference in spee...
Stephan Waack, Oliver Keller, Roman Asper, Thomas ...
BMCBI
2006
149views more  BMCBI 2006»
13 years 7 months ago
Curation of viral genomes: challenges, applications and the way forward
Background: Whole genome sequence data is a step towards generating the 'parts list' of life to understand the underlying principles of Biocomplexity. Genome sequencing ...
Urmila Kulkarni-Kale, Shriram Bhosle, G. Sunitha M...
BMCBI
2006
114views more  BMCBI 2006»
13 years 7 months ago
Evaluation and comparison of mammalian subcellular localization prediction methods
Background: Determination of the subcellular location of a protein is essential to understanding its biochemical function. This information can provide insight into the function o...
Josefine Sprenger, J. Lynn Fink, Rohan D. Teasdale