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» Ensemble Based Data Fusion for Gene Function Prediction
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EVOW
2003
Springer
14 years 3 months ago
Comparison of AdaBoost and Genetic Programming for Combining Neural Networks for Drug Discovery
Genetic programming (GP) based data fusion and AdaBoost can both improve in vitro prediction of Cytochrome P450 activity by combining artificial neural networks (ANN). Pharmaceuti...
William B. Langdon, S. J. Barrett, Bernard F. Buxt...
BMCBI
2010
104views more  BMCBI 2010»
13 years 5 months ago
A systematic study of genome context methods: calibration, normalization and combination
Background: Genome context methods have been introduced in the last decade as automatic methods to predict functional relatedness between genes in a target genome using the patter...
Luciana Ferrer, Joseph M. Dale, Peter D. Karp
BMCBI
2008
117views more  BMCBI 2008»
13 years 10 months ago
A probabilistic framework to predict protein function from interaction data integrated with semantic knowledge
Background: The functional characterization of newly discovered proteins has been a challenge in the post-genomic era. Protein-protein interactions provide insights into the funct...
Young-Rae Cho, Lei Shi, Murali Ramanathan, Aidong ...
BMCBI
2008
128views more  BMCBI 2008»
13 years 10 months ago
Validation of an NSP-based (negative selection pattern) gene family identification strategy
Background: Gene family identification from ESTs can be a valuable resource for analysis of genome evolution but presents unique challenges in organisms for which the entire genom...
Ronald L. Frank, Cyriac Kandoth, Fikret Erç...
BMCBI
2008
200views more  BMCBI 2008»
13 years 10 months ago
Defining functional distances over Gene Ontology
Background: A fundamental problem when trying to define the functional relationships between proteins is the difficulty in quantifying functional similarities, even when well-stru...
Angela del Pozo, Florencio Pazos, Alfonso Valencia