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» Ensemble Based Data Fusion for Gene Function Prediction
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RECOMB
2003
Springer
14 years 10 months ago
An integrated probabilistic model for functional prediction of proteins
We develop an integrated probabilistic model to combine protein physical interactions, genetic interactions, highly correlated gene expression network, protein complex data, and d...
Minghua Deng, Ting Chen, Fengzhu Sun
ALMOB
2006
155views more  ALMOB 2006»
13 years 10 months ago
A phylogenetic generalized hidden Markov model for predicting alternatively spliced exons
Background: An important challenge in eukaryotic gene prediction is accurate identification of alternatively spliced exons. Functional transcripts can go undetected in gene expres...
Jonathan E. Allen, Steven L. Salzberg
CCE
2005
13 years 10 months ago
Selecting maximally informative genes
Microarray experiments are emerging as one of the main driving forces in modern biology. By allowing the simultaneous monitoring of the expression of the entire genome for a given...
Ioannis P. Androulakis
BMCBI
2006
152views more  BMCBI 2006»
13 years 10 months ago
Predicting deleterious nsSNPs: an analysis of sequence and structural attributes
Background: There has been an explosion in the number of single nucleotide polymorphisms (SNPs) within public databases. In this study we focused on non-synonymous protein coding ...
Richard J. B. Dobson, Patricia B. Munroe, Mark J. ...
BMCBI
2006
123views more  BMCBI 2006»
13 years 10 months ago
Characterizing disease states from topological properties of transcriptional regulatory networks
Background: High throughput gene expression experiments yield large amounts of data that can augment our understanding of disease processes, in addition to classifying samples. He...
David Tuck, Harriet Kluger, Yuval Kluger