Peptide-based vaccines, in which small peptides derived from target proteins (epitopes) are used to provoke an immune reaction, have attracted considerable attention recently as a...
The ability to predict antigenic sites on proteins is crucial for the production of synthetic peptide vaccines and synthetic peptide probes of antibody structure. Large number of ...
Background: The main processing pathway for MHC class I ligands involves degradation of proteins by the proteasome, followed by transport of products by the transporter associated...
Irini A. Doytchinova, Pingping Guan, Darren R. Flo...
Background: Most methods available to predict protein epitopes are sequence based. There is a need for methods using 3D information for prediction of discontinuous epitopes and de...
Background: T cells recognize a complex between a specific major histocompatibility complex (MHC) molecule and a particular pathogen-derived epitope. A given epitope will elicit a...
Huynh-Hoa Bui, John Sidney, Kenny Dinh, Scott Sout...